Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Hill, Stephen A., Benito-Alifonso, David., Morgan, David John ORCID: https://orcid.org/0000-0002-6571-5731, Davis, Sean A., Berry, Monica and Galan, M. Carmen 2016. Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery. Nanoscale 8 (44) , pp. 18630-18634. 10.1039/C6NR07336K

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Abstract

A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Cardiff Catalysis Institute (CCI) Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	RSC Publishing
ISSN:	2040-3364
Funders:	EPSRC
Date of First Compliant Deposit:	1 December 2016
Date of Acceptance:	20 October 2016
Last Modified:	05 May 2023 18:23
URI:	https://orca.cardiff.ac.uk/id/eprint/96551

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