Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging

Pope, Simon J. A. ORCID: https://orcid.org/0000-0001-9110-9711, Langdon-Jones, Emily, Jones, Ariana, Williams, Catrin Ffion ORCID: https://orcid.org/0000-0001-8619-2581, Hayes, Anthony Joseph, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 and Mottram, Huw James 2017. Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging. European Journal of Inorganic Chemistry 2017 (3) , pp. 759-766. 10.1002/ejic.201601271 Item availability restricted.

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Abstract

Two dipicolyamino-conjugated anthracene-1,9-dicarboximide fluorophores and their corresponding ReI complexes have been synthesised and photophysically examined. All species were fluorescent in the visible region at about 490 nm with lifetimes up to 16 ns. The anticancer potency of the ligands and complexes was demonstrated across a range of cancer cell lines (LOVO, PC3, A549, MCF-7). Cell imaging studies with MCF7 cells and Schizosaccharomyces pombe show that these fluorophores exhibit variable intracellular localisation patterns that are structure-dependent.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Wiley
ISSN:	1434-1948
Date of First Compliant Deposit:	30 January 2017
Date of Acceptance:	18 October 2016
Last Modified:	13 Nov 2024 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/97718

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