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Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins

Syed, Yasir A., Baer, Alexandra S., Lubec, Gert, Hoeger, Harald, Widhalm, Georg and Kotter, Mark R. 2008. Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins. Neurosurgical Focus 24 (3-4) , E5. 10.3171/FOC/2008/24/3-4/E4

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Promoting repair of central nervous system (CNS) white matter represents an important approach to easing the course of a number of tragic neurological diseases. For this purpose, strategies are currently being evaluated for transplanting cells capable of generating new oligodendrocytes into areas of demyelination and/or enhancing the potential of endogenous stem/precursor cells to give rise to new oligodendrocytes. Emerging evidence, however, indicates that increasing the presence of cells capable of forming new myelin sheaths is not sufficient to promote repair because of unknown inhibitors that accumulate in lesions as a consequence of myelin degeneration and impair the generation of new oligodendrocytes. The aim of the present study was to characterize the nature of the inhibitory molecules present in myelin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Association of Neurological Surgeons
ISSN: 1092-0684
Last Modified: 04 Jun 2017 09:41

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