Probing the molecular recognition of a DNA-RNA hybrid duplex

Wheelhouse, Richard T., Garbett, Nichola C., Buurma, Niklaas Jan ORCID: https://orcid.org/0000-0003-0260-5057 and Chaires, Jonathan B. 2010. Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition 49 (18) , pp. 3207-3210. 10.1002/anie.200907235

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Abstract

Curiouser and curiouser! A biarylpyrimidine ligand shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	DNA–RNA hybrids; drug discovery; molecular recognition; pyrimidine; RNaseH
Publisher:	Wiley
ISSN:	1433-7851
Last Modified:	18 Oct 2022 12:26
URI:	https://orca.cardiff.ac.uk/id/eprint/9831

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