Phase-contrast micro-computed tomography measurements of the intraocular pressure-induced deformation of the porcine lamina cribrosa

Coudrillier, Baptiste, Geraldes, Diogo M., Vo, Nghia T., Atwood, Robert, Reinhard, Christina, Campbell, Ian C., Raji, Yazdan, Albon, Julie ORCID: https://orcid.org/0000-0002-3029-8245, Abel, Richard L. and Ethier, C. Ross 2016. Phase-contrast micro-computed tomography measurements of the intraocular pressure-induced deformation of the porcine lamina cribrosa. IEEE Transactions on Medical Imaging 35 (4) , pp. 988-999. 10.1109/TMI.2015.2504440

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Abstract

The lamina cribrosa (LC) is a complex mesh-like tissue in the posterior eye. Its biomechanical environment is thought to play a major role in glaucoma, the second most common cause of blindness. Due to its small size and relative inaccessibility, high-resolution measurements of LC deformation, important in characterizing LC biomechanics, are challenging. Here we present a novel noninvasive imaging method, which enables measurement of the three-dimensional deformation of the LC caused by acute elevation of intraocular pressure (IOP). Posterior segments of porcine eyes were imaged using synchrotron radiation phase contrast micro-computed tomography (PC μCT) at IOPs between 6 and 37 mmHg. The complex trabecular architecture of the LC was reconstructed with an isotropic spatial resolution of 3.2 μm. Scans acquired at different IOPs were analyzed with digital volume correlation (DVC) to compute full-field deformation within the LC. IOP elevation caused substantial tensile, shearing and compressive devformation within the LC, with maximum tensile strains at 30 mmHg averaging 5.5%, and compressive strains reaching 20%. We conclude that PC μCT provides a novel high-resolution method for imaging the LC, and when combined with DVC, allows for full-field 3D measurement of ex vivo LC biomechanics at high spatial resolution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Uncontrolled Keywords:	Biomechanics, strain measurements, x-ray tomography
Publisher:	Institute of Electrical and Electronics Engineers (IEEE)
ISSN:	0278-0062
Date of Acceptance:	20 November 2015
Last Modified:	21 Oct 2022 07:18
URI:	https://orca.cardiff.ac.uk/id/eprint/99581

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