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Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity

Koelewijn, Loes, Bompas, Aline, Tales, Andrea, Brookes, Matthew J., Muthukumaraswamy, Suresh D., Bayer, Antony and Singh, Krish D. 2017. Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity. Clinical Neurophysiology 128 (11) , pp. 2347-2357. 10.1016/j.clinph.2017.04.018

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Objective: Neuroimaging studies in Alzheimer’s disease (AD) yield conflicting results due to selective investigation. We conducted a comprehensive magnetoencephalography study of connectivity changes in AD and healthy ageing in the resting-state. Methods: We performed a whole-brain, source-space assessment of oscillatory neural signalling in multiple frequencies comparing AD patients, elderly and young controls. We compared eyes-open and closed group oscillatory envelope activity in networks obtained through temporal independent component analysis, and calculated whole-brain node-based amplitude and phase connectivity. Results: In bilateral parietotemporal areas, oscillatory envelope amplitude increased with healthy ageing, whereas both local amplitude and node-to-global connectivity decreased with AD. AD-related decreases were spatially specific and restricted to the alpha and beta bands. A significant proportion of the variance in areas of peak group difference was explained by cognitive integrity, in addition to group. None of the groups differed in phase connectivity. Results were highly similar for eyes-open and closed resting-state. Conclusions: These results support the disconnection syndrome hypothesis and suggest that AD shows distinct and unique patterns of disrupted neural functioning, rather than accelerated healthy ageing. Significance: Whole-brain assessments show that disrupted regional oscillatory envelope amplitude and connectivity in the alpha and beta bands play a key role in AD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Additional Information: This is an open access article under the terms of the CC-BY license.
Publisher: Elsevier
ISSN: 1388-2457
Funders: Medical Research Council (MRC)
Date of First Compliant Deposit: 25 April 2017
Date of Acceptance: 17 April 2017
Last Modified: 21 Aug 2022 08:25

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