Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells

Ahmed, Nisar ORCID: https://orcid.org/0000-0002-7954-5251, Shirinfar, Bahareh, Miriyala, Vijay Madhav, Choi, Seong-Kyoon, Lee, Kyeong-Min, Jeon, Won Bae, Park, Yu Shin and Nam, Hong Gil 2015. A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells. Supramolecular Chemistry 27 (7-8) , pp. 478-483. 10.1080/10610278.2014.989851

Full text not available from this repository.

Abstract

Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membrane-permeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson's disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: RNA recognition; Host–guest chemistry; Cationic probe; Confocal microscopy
Publisher: Taylor & Francis
ISSN: 1061-0278
Date of Acceptance: 17 November 2014
Last Modified: 21 Oct 2022 07:39
URI: https://orca.cardiff.ac.uk/id/eprint/100419

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item