A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells

Ahmed, Nisar ORCID: https://orcid.org/0000-0002-7954-5251, Shirinfar, Bahareh, Miriyala, Vijay Madhav, Choi, Seong-Kyoon, Lee, Kyeong-Min, Jeon, Won Bae, Park, Yu Shin and Nam, Hong Gil 2015. A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells. Supramolecular Chemistry 27 (7-8) , pp. 478-483. 10.1080/10610278.2014.989851

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Abstract

Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membrane-permeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson's disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	RNA recognition; Host–guest chemistry; Cationic probe; Confocal microscopy
Publisher:	Taylor & Francis
ISSN:	1061-0278
Date of Acceptance:	17 November 2014
Last Modified:	21 Oct 2022 07:39
URI:	https://orca.cardiff.ac.uk/id/eprint/100419

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