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Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial

Williams, Hywel C., Wojnarowska, Fenella, Kirtschig, Gudula, Mason, James, Godec, Thomas R., Schmidt, Enno, Chalmers, Joanne R., Childs, Margaret, Walton, Shernaz, Harman, Karen, Chapman, Anna, Whitham, Diane, Nunn, Andrew J., Adams, J., Akhras, V., Anstey, A., Barnard, C., Bell, H., Blackford, S., Bröcker, E., Carmichael, A., Coelho, R. R., Craig, F., Davies, K., Ellis, R., English, J., Gläser, R., Groves, R., Günthert, C., Hampton, P. J., Hepburn, N., Hügel, R., Hussain, K., Ingram, J. ORCID:, Layton, A. M., Levell, N. J., Lewis, V., Malhomme, H., Omerod, A., Patel, G., Rallan, R., Ravenscroft, J., Santander, H., Steinbrink, K., Sticherling, M., Thomas, C., Vatve, M., van Beek, N., Venning, V., Veysey, E., Wachsmuth, R., Wahie, S., Walker, B., Walsh, M., Wee, J., Westmoreland, M., Wong, G., Ferguson, Adam, Verpetinske, Indre, Duarte-Williamson, Emilia, Antony, Fiona, Bower, Chris, Gawkrodger, David, Taghipour, Kathy, Dunnill, M. G. S., Waters, Alex, Bottomley, Walter, Wright, Andrew, Sterling, Jane, Azam, Adzura, Gibbs, Sam, Luger, Thomas, Salvary, Ingrid, Lovell, Chris, Ilchyshyn, Andrew, Gibbon, Karem, Nik, Marinella, Charles-Holmes, Robert and Lavery, A. Lloyd 2017. Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial. Lancet 389 (10079) , pp. 1630-1638. 10.1016/S0140-6736(17)30560-3

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Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids. Methods We did a pragmatic, multicentre, parallel-group randomised controlled trial of adults with bullous pemphigoid (three or more blisters at two or more sites and linear basement membrane IgG or C3). Participants were randomly assigned to doxycycline (200 mg per day) or prednisolone (0·5 mg/kg per day) using random permuted blocks of randomly varying size, and stratified by baseline severity (3–9, 10–30, and >30 blisters for mild, moderate, and severe disease, respectively). Localised adjuvant potent topical corticosteroids (<30 g per week) were permitted during weeks 1–3. The non-inferiority primary effectiveness outcome was the proportion of participants with three or fewer blisters at 6 weeks. We assumed that doxycycline would be 25% less effective than corticosteroids with a 37% acceptable margin of non-inferiority. The primary safety outcome was the proportion with severe, life-threatening, or fatal (grade 3–5) treatment-related adverse events by 52 weeks. Analysis (modified intention to treat [mITT] for the superiority safety analysis and mITT and per protocol for non-inferiority effectiveness analysis) used a regression model adjusting for baseline disease severity, age, and Karnofsky score, with missing data imputed. The trial is registered at ISRCTN, number ISRCTN13704604. Findings Between March 1, 2009, and Oct 31, 2013, 132 patients were randomly assigned to doxycycline and 121 to prednisolone from 54 UK and seven German dermatology centres. Mean age was 77·7 years (SD 9·7) and 173 (68%) of 253 patients had moderate-to-severe baseline disease. For those starting doxycycline, 83 (74%) of 112 patients had three or fewer blisters at 6 weeks compared with 92 (91%) of 101 patients on prednisolone, an adjusted difference of 18·6% (90% CI 11·1–26·1) favouring prednisolone (upper limit of 90% CI, 26·1%, within the predefined 37% margin). Related severe, life-threatening, and fatal events at 52 weeks were 18% (22 of 121) for those starting doxycycline and 36% (41 of 113) for prednisolone (mITT), an adjusted difference of 19·0% (95% CI 7·9–30·1), p=0·001. Interpretation Starting patients on doxycycline is non-inferior to standard treatment with oral prednisolone for short-term blister control in bullous pemphigoid and significantly safer in the long-term.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: On behalf of the UK Dermatology Clinical Trials Network BLISTER Study Group. This is an open access article under the CC BY license.
Publisher: Elsevier
ISSN: 0140-6736
Date of First Compliant Deposit: 12 May 2017
Date of Acceptance: 6 March 2017
Last Modified: 05 May 2023 20:07

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