Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Christie, Jamieson K., Ainsworth, Richard I, Ruiz Hernandez, Sergio Ernesto ORCID: https://orcid.org/0000-0003-3149-7331 and De Leeuw, Nora Henriette ORCID: https://orcid.org/0000-0002-8271-0545 2017. Structures and properties of phosphate-based bioactive glasses from computer simulation: a review. Journal of Materials Chemistry B 5 (27) , pp. 5297-5306. 10.1039/C7TB01236E

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Abstract

Phosphate-based bioactive glasses (PBGs) dissolve harmlessly in the body with a dissolution rate which depends sensitively on composition. This makes them proposed vectors for e.g. drug delivery, or other applications where an active component needs to be delivered at a therapeutically appropriate rate. Molecular dynamics (MD) simulations provide atomic-level structural information about PBG compositions. We review recent work to show that MD is an excellent tool to unravel the connections between the PBG glass composition, its atomic structure, and its dissolution rate, which can help to optimise PBGs for specific medical applications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	2050-750X
Date of First Compliant Deposit:	21 June 2017
Date of Acceptance:	15 June 2017
Last Modified:	18 Nov 2023 17:49
URI:	https://orca.cardiff.ac.uk/id/eprint/101638

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