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A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management

Hachach-Haram, Nadine, Bystrzonowski, Nicola, Kanapathy, Muholan, Smith, Oliver, Harding, Keith Gordon, Mosahebi, Ash and Richards, Toby 2017. A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management. International Wound Journal 14 (1) , pp. 241-249. 10.1111/iwj.12595

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Current wound management through the use of a split-thickness skin graft often requires hospital admission, a period of immobility, attentive donor site wound care and pain management. This study evaluates the feasibility of using a novel epidermal graft-harvesting device (CelluTome) that allows pain-free epidermal skin grafting in the outpatient clinic setting. A prospective series of 35 patients was performed in 2 centres, involving 10 acute and 25 chronic wounds. All patients were subjected to epidermal grafting in the outpatient specialist clinic, without the use of anaesthesia, and allowed to return home after the procedure. Completely healed wounds were noted in 22 patients (62·9%). The overall mean time for 50% and 100% reduction in wound size was 3·31 ± 2·33 and 5·91 ± 3·48 weeks, respectively. There was no significant difference in healing times between the acute and chronic wounds (50% reduction in wound size; acute 2·20 ± 0·91 weeks versus chronic 3·73 ± 2·63 weeks, P = 0·171. Hundred percent reduction in wound size; acute 4·80 ± 1·61 weeks versus chronic 6·83 ± 4·47 weeks, P = 0·183). The mean time for donor site healing was 5·49 ± 1·48 days. The mean pain score during graft harvest was 1·42 ± 0·95, and the donor site Vancouver Scar Scale was 0 for all cases at 6 weeks. This automated device offers autologous skin harvesting in the outpatient setting with minimal or no pain and a scar free donor site, equally benefiting both the acute and chronic wounds. It has the potential to save NHS resources by eliminating the need for theatre space and a hospital bed while at the same time benefiting patient care.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Wiley-Blackwell
ISSN: 1742-4801
Date of Acceptance: 24 February 2016
Last Modified: 28 Jun 2017 14:11

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