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Effect of preterm birth on exercise capacity: a systematic review and meta-analysis

Edwards, Martin, Kotecha, Sarah J., Lowe, John, Watkins, William ORCID:, Henderson, A. John and Kotecha, Sailesh ORCID: 2015. Effect of preterm birth on exercise capacity: a systematic review and meta-analysis. Pediatric Pulmonology 50 (3) , pp. 293-301. 10.1002/ppul.23117

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Background Survivors of preterm-birth have increased prevalence of respiratory, cardiovascular, and neurological diseases in later life however, the overall impact of prematurity on cardiorespiratory exercise capacity is unclear. Objective We, therefore, systematically reviewed the literature on cardiorespiratory exercise capacity in survivors of preterm birth. Methodology Relevant studies up to March 2013 were searched using eight electronic health databases. Studies reporting exercise capacity in participants born preterm (<37 weeks) were included. The main outcome of interest was oxygen uptake (math formula) at maximal exercise. Data were categorized into four groups: (i) preterm-born subjects including those with or without bronchopulmonary dysplasia (BPD) but excluding study groups biased towards BPD; (ii) preterm-born subjects (BPD excluded); (iii) preterm-born subjects who had BPD28 (defined as oxygen dependency at 28 days of life) in infancy; (iv) preterm born subjects with BPD36 (oxygen dependency at 36 weeks post menstrual age) in infancy. Results From 9,341 abstracts, 22 included publications reported math formula in ml/kg/min from 685 preterm and 680 term-born subjects. Overall 20 studies reported results for preterm-born subjects including BPD; 14 studies for the preterm group excluding BPD; 10 studies for the BPD28 group; and 8 studies for BPD36 group. The mean differences (95% CI) for the four groups were −2.20 (−3.70, −0.70) ml/kg/min; −2.26 (−4.44, −0.07 ml/kg/min; −3.04 (−5.48, −0.61) ml/kg/min, and −3.05 (−5.93, −0.18) ml/kg/min, respectively. Conclusion Despite marked deficits in spirometry, preterm-born children have a marginally decreased math formula, which is unlikely to be of great clinical significance

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley-Blackwell
ISSN: 8755-6863
Date of Acceptance: 10 September 2014
Last Modified: 15 Apr 2023 01:16

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