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Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study

Taylor, Peter N. ORCID:, Sayers, Adrian, Okosieme, Onyebuchi, Das, Gautam, Draman, Mohd S., Tabasum, Arshiya, Abusahmin, Hussam, Rahman, Mohammad, Stevenson, Kirsty, Groom, Alix, Northstone, Kate, Woltersdorf, Wolf, Taylor, Andrew ORCID:, Ring, Susan, Lazarus, John H., Gregory, John W., Rees, Aled ORCID:, Timpson, Nicholas and Dayan, Colin M. ORCID: 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102 (7) , pp. 2508-2515. 10.1210/jc.2016-3605

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Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally through childhood. Objective: To assess changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels over childhood and their interrelationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children, a population-based birth cohort. Participants: A total of 4442 children who had thyroid function measured at age 7, and 1263 children who had thyroid function measured at age 15. Eight hundred eighty-four children had measurements at both ages. Main Outcome Measures: Reference ranges for TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), their longitudinal stability, and interrelationships. Results: Children at age 7 years had a higher FT3 [6.17 pmol/L, standard deviation (SD) 0.62] than children at age 15 (5.83 pmol/L, SD 0.74); P , 0.0001 with 23.2% of children at age 7 having FT3 above the adult reference range. Higher FT3 levels at age 7 in boys (P = 0.0001) and girls (P = 0.04) were associated with attainment of a more advanced pubertal stage at age 13. TSH was positively associated with FT3 at age 7 and age 15 even after adjusting for confounders. In contrast, TSH was negatively associated with FT4

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Additional Information: This article has been published under the terms of the Creative Commons Attribution License(CCBY;,whichpermitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Publisher: Oxford University Press
ISSN: 0021-972X
Date of First Compliant Deposit: 10 July 2017
Date of Acceptance: 24 April 2017
Last Modified: 11 Oct 2023 18:50

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