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Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study

Taylor, Peter N., Sayers, Adrian, Okosieme, Onyebuchi, Das, Gautam, Draman, Mohd S., Tabasum, Arshiya, Abusahmin, Hussam, Rahman, Mohammad, Stevenson, Kirsty, Groom, Alix, Northstone, Kate, Woltersdorf, Wolf, Taylor, Andrew, Ring, Susan, Lazarus, John H., Gregory, John W., Rees, Aled, Timpson, Nicholas and Dayan, Colin M. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102 (7) , pp. 2508-2515. 10.1210/jc.2016-3605

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Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally through childhood. Objective: To assess changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels over childhood and their interrelationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children, a population-based birth cohort. Participants: A total of 4442 children who had thyroid function measured at age 7, and 1263 children who had thyroid function measured at age 15. Eight hundred eighty-four children had measurements at both ages. Main Outcome Measures: Reference ranges for TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), their longitudinal stability, and interrelationships. Results: Children at age 7 years had a higher FT3 [6.17 pmol/L, standard deviation (SD) 0.62] than children at age 15 (5.83 pmol/L, SD 0.74); P , 0.0001 with 23.2% of children at age 7 having FT3 above the adult reference range. Higher FT3 levels at age 7 in boys (P = 0.0001) and girls (P = 0.04) were associated with attainment of a more advanced pubertal stage at age 13. TSH was positively associated with FT3 at age 7 and age 15 even after adjusting for confounders. In contrast, TSH was negatively associated with FT4

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Additional Information: This article has been published under the terms of the Creative Commons Attribution License(CCBY;,whichpermitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Publisher: Oxford University Press
ISSN: 0021-972X
Date of First Compliant Deposit: 10 July 2017
Date of Acceptance: 24 April 2017
Last Modified: 22 May 2022 07:40

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