Directed lithiation and substitution of pyridine derivatives

El-Hiti, Gamal A., Smith, Keith ORCID: https://orcid.org/0000-0003-4838-5651 and Hegazy, Amany S. 2015. Directed lithiation and substitution of pyridine derivatives. Heterocycles 91 (3) , pp. 479-504.

Full text not available from this repository.

Abstract

Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Publisher:	Elsevier
ISSN:	0385-5414
Last Modified:	01 Sep 2017 12:03
URI:	https://orca.cardiff.ac.uk/id/eprint/102289

Citation Data

Cited 12 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item