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Impact of cytological sampling on EGFR mutation testing in stage III-IV lung adenocarcinoma

Davies, Rhian Siân, Smith, Christian, Edwards, Gwenllian, Butler, Rachel, Parry, Diane and Lester, Jason Francis 2017. Impact of cytological sampling on EGFR mutation testing in stage III-IV lung adenocarcinoma. Lung Cancer International 2017 , pp. 1-6. 10.1155/2017/9614938

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Objectives. There have been advances in the identification and understanding of molecular subsets of lung cancer, defined by specific oncogenic aberrations. A number of actionable genetic alterations have been identified, such as the epidermal growth factor receptor (EGFR) mutation. We aimed to establish the reasons why patients were not undergoing EGFR mutation testing at the time of histological diagnosis. Methods. The records of 70 patients with advanced adenocarcinoma of the lung managed through a single multidisciplinary team at a single institution were reviewed. Data were collected on method of tumour sample collection, whether this was sent for EGFR testing, and the result. Results. Seventy patients were identified. In 21/25 (84%) cases, cytological sampling was sufficient for EGFR mutation analysis, compared with 40/45 (89%) cases with histological sampling. EGFR mutation testing was not carried out in 22/70 (31.4%) patients. There was insufficient tumour sample for EGFR testing in 9/22 (40.9%) patients. Other reasons for not testing included poor patient fitness and problems in the diagnostic pathway. Conclusions. In this series, cytological tumour sampling was not the predominant reason why cancers failed to have EGFR mutation status established.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Hindawi
ISSN: 2090-3197
Date of First Compliant Deposit: 7 December 2017
Date of Acceptance: 20 February 2017
Last Modified: 07 Dec 2017 12:36

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