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Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling

Latinkic, Branko ORCID:, Mercurio, S., Bennett, B., Hirst, E. M. A., Xu, Q., Lau, L. F., Mohun, Timothy. J. and Smith, J. C. 2003. Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development 130 , pp. 2429-2441. 10.1242/dev.00449

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Cyr61 is a secreted, heparin-binding, extracellular matrix-associated protein whose activities include the promotion of adhesion and chemotaxis, and the stimulation of fibroblast and endothelial cell growth. Many, if not all, of these activities of Cyr61 are mediated through interactions with integrins. We explore the role of Cyr61 in the early development of Xenopus laevis. Gain- and loss-of-function experiments show that Xcyr61 is required for normal gastrulation movements. This role is mediated in part through the adhesive properties of Xcyr61 and its related ability to modulate assembly of the extracellular matrix. In addition, Xcyr61 can, in a context-dependent manner, stimulate or inhibit signalling through the Wnt pathway. These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
ISSN: 0950-1991
Last Modified: 17 Oct 2022 08:46

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