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The microbiota and autoimmunity: their role in thyroid autoimmune diseases

Köhling, Hedda L., Plummer, Sue F., Marchesi, Julian R. ORCID:, Davidge, Kelly S. and Ludgate, Marian 2017. The microbiota and autoimmunity: their role in thyroid autoimmune diseases. Clinical Immunology 183 , pp. 63-74. 10.1016/j.clim.2017.07.001

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Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD) has been an object of intensive research. The last decade has witnessed many studies on Yersinia enterocolitica, Helicobacter pylori and other bacterial organisms and their potential impact on GD. Retrospective, prospective and molecular binding studies have been performed with contrary outcomes. Until now it is not clear whether bacterial infections can trigger autoimmune thyroid disease. Common risk factors for GD (gender, smoking, stress, and pregnancy) reveal profound changes in the bacterial communities of the gut compared to that of healthy controls but a pathogenetic link between GD and dysbiosis has not yet been fully elucidated. Conventional bacterial culture, in vitro models, next generation and high-throughput DNA sequencing are applicable methods to assess the impact of bacteria in disease onset and development. Further studies on the involvement of bacteria in GD are needed and may contribute to the understanding of pathogenetic processes. This review will examine available evidence on the subject.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 1521-6616
Date of First Compliant Deposit: 25 July 2017
Date of Acceptance: 5 July 2017
Last Modified: 07 Nov 2023 01:47

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