Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance

Zabkiewicz, Catherine, Resaul, Jeyna, Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2017. Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance. Endocrine-Related Cancer 24 (10) , R349-R366. 10.1530/ERC-17-0139

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Abstract

Bone morphogenetic proteins (BMPs) belong to the TGF-β super family, and are essential for regulation of foetal development, tissue differentiation and homeostasis, and a multitude of cellular functions. Naturally, this has led to the exploration of aberrance in this highly regulated system as a key factor in tumourigenesis. Originally identified for their role in osteogenesis and bone turnover, attention has been turned to the potential role of BMPs in tumour metastases to, and progression within, the bone niche. This is particularly pertinent to breast cancer, which commonly metastasises to bone, and in which studies have revealed aberrations of both BMP expression and signalling which correlate clinically with breast cancer progression. Ultimately a BMP profile could provide new prognostic disease markers. As the evidence suggests a role for BMPs in regulating breast tumour cellular function, in particular interactions with tumour stroma and the bone metastatic microenvironment, there may be novel therapeutic potential in targeting BMP signalling in breast cancer. This review provides an update on the current knowledge of BMP abnormalities and their implication in the development and progression of breast cancer, particularly in the disease specific bone metastasis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	BioScientifica
ISSN:	1351-0088
Date of First Compliant Deposit:	25 August 2017
Date of Acceptance:	21 July 2017
Last Modified:	20 Nov 2024 21:00
URI:	https://orca.cardiff.ac.uk/id/eprint/102961

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