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Management of thyroid eye disease in the United Kingdom: A multi-centre thyroid eye disease audit

Mellington, F. E., Dayan, Colin M. ORCID:, Dickinson, A. J., Hickey, J. L., MacEwen, C. J., McLaren, J., Perros, P., Rose, G. E., Uddin, J., Vaidya, B., Foley, P., Lazarus, J. H., Mitchell, A. and Ezra, D. G. 2017. Management of thyroid eye disease in the United Kingdom: A multi-centre thyroid eye disease audit. Orbit 36 (3) , pp. 159-169. 10.1080/01676830.2017.1280057

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This article aims to provide baseline data and highlight any major deficiencies in the current level of care provided for adult patients with thyroid eye disease (TED). We undertook a prospective, nonrandomized cross-sectional multicenter observational study. During a 3-month period June–August 2014, consecutive adult patients with TED who presented to nominated specialist eye clinics in the United Kingdom, completed a standardized questionnaire. Main outcome measures were: demographics, time from diagnosis to referral to tertiary centre, time from referral to review in specialist eye clinic, management of thyroid dysfunction, radioiodine and provision of steroid prophylaxis, smoking, and TED classification. 91 patients (mean age 47.88 years) were included. Female-to-male ratio was 6:1. Mean time since first symptoms of TED = 27.92 (73.71) months; from first visit to any doctor with symptoms to diagnosis = 9.37 (26.03) months; from hyperthyroidism diagnosis to euthyroidism 12.45 (16.81) months. First, 13% had received radioiodine. All those with active TED received prophylactic steroids. Seven patients who received radioiodine and did not have TED at the time went on to develop it. Then, 60% patients were current or ex-smokers. 63% current smokers had been offered smoking cessation advice. 65% patients had active TED; 4% had sight-threatening TED. A large proportion of patients (54%) were unaware of their thyroid status. Not enough patients are being provided with smoking cessation advice and information on the impact of smoking on TED and control of thyroid function.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Taylor & Francis
ISSN: 0167-6830
Date of First Compliant Deposit: 22 August 2017
Date of Acceptance: 5 January 2017
Last Modified: 06 Nov 2023 15:44

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