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Capturing "extraordinary" soft-assembled charge-like polypeptides as a strategy for nanocarrier design

Duro-Castano, Aroa, Nebot, Vicent J., Niño-Pariente, Amaya, Armiñán, Ana, Arroyo-Crespo, Juan J., Paul, Alison ORCID:, Feiner-Gracia, Natalia, Albertazzi, Lorenzo and Vicent, María J. 2017. Capturing "extraordinary" soft-assembled charge-like polypeptides as a strategy for nanocarrier design. Advanced Materials 29 (39) , 1702888. 10.1002/adma.201702888

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The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous “ordinary–extraordinary” phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 0935-9648
Date of First Compliant Deposit: 31 August 2017
Date of Acceptance: 6 July 2017
Last Modified: 22 Oct 2022 13:35

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