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A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

Kelsey, L., Powell, J., Norman, P., Miller, CARDIFF and Doyle, B. 2017. A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm. International Journal for Numerical Methods in Biomedical Engineering 33 (5) , e2821. 10.1002/cnm.2821

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Abstract

Aneurysms of the common iliac artery (CIAA) are typically found in association with an abdominal aortic aneurysm (AAA). Isolated CIAAs, in the absence of an AAA, are uncommon. Similar to AAAs, CIAA may develop intraluminal thrombus (ILT). As isolated CIAAs have a contralateral common iliac artery for comparison, they provide an opportunity to study the hemodynamic mechanisms behind ILT formation. In this study, we compared a large isolated CIAA and the contralateral iliac artery using computational fluid dynamics to determine if hemodynamic metrics correlate with the location of ILT. We performed a comprehensive computational fluid dynamics study and investigated the residence time of platelets and monocytes, velocity fields, time-averaged wall shear stress, oscillatory shear index, and endothelial cell activation potential. We then correlated these data to ILT burden determined with computed tomography. We found that high cell residence times, low time-averaged wall shear stress, high oscillatory shear index, and high endothelial cell activation potential all correlate with regions of ILT development. Our results show agreement with previous hypotheses of thrombus formation in AAA and provide insights into the computational hemodynamics of iliac artery aneurysms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Subjects: T Technology > T Technology (General)
Uncontrolled Keywords: computational fluid dynamics; iliac aneurysm; intraluminal thrombus; wall shear stress
Publisher: John Wiley & Sons, Ltd.
ISSN: 20407939
Date of Acceptance: 2 July 2016
Last Modified: 15 Jul 2019 13:08
URI: https://orca.cardiff.ac.uk/id/eprint/104179

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