Numerical study of magnetic particles concentration in biofluid (blood) under the influence of high gradient magnetic field in microchannel

Loukopoulos, V. C., Bourantas, G. C., Labropoulos, D., Nikiforidis, V. M. G., Bordas, Stephane ORCID: https://orcid.org/0000-0001-8634-7002 and Nikiforidis, G. C. 2016. Numerical study of magnetic particles concentration in biofluid (blood) under the influence of high gradient magnetic field in microchannel. Presented at: 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece, 5-10 June 2016. Published in: Papadrakakis, M., Papadopoulos, V., Stefanou, G. and Plevris, V. eds. ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering. , vol.1 Athens, Greece: National Technical University of Athens, pp. 1084-1092. 10.7712/100016.1871.9717

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Abstract

A meshless numerical scheme is developed in order to simulate the magnetically mediated separation of biological mixture used in lab-on-chip devices as solid carriers for capturing, transporting and detecting biological magnetic labeled entities, as well as for drug delivering, magnetic hyperthermia treatment, magnetic resonance imaging, magnetofection, etc. Due to the imposed magnetic field stagnation regions are developed, leading to the accumulation of the magnetic labeled species and finally to their collection from the heterogeneous mixture. The role of (i) the intensity of magnetic field and its gradient, (ii) the position of magnetic field, (iii) the magnetic susceptibility of magnetic particles, (iv) the volume concentration of magnetic particles and their size, (v) the flow velocity in the magnetic fluidic interactions and interplay between the magnetophoretic mass transfer and molecular diffusion are thoroughly investigated. Both Newtonian and non-Newtonian blood flow models are considered.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Engineering
Uncontrolled Keywords:	Biomagnetic separation; Drug delivery; Hyperthermia treatment; Magnetophoretic mass transfer; Meshless; Molecular diffusion; Non Newtonian; Two-phase flow
Additional Information:	Copyright remains with the authors.
Publisher:	National Technical University of Athens
ISBN:	9786188284401
Related URLs:	Publisher
Date of First Compliant Deposit:	8 September 2017
Last Modified:	22 Oct 2022 13:43
URI:	https://orca.cardiff.ac.uk/id/eprint/104471

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