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Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type

Green, Elaine K., Di Florio, Arianna ORCID:, Forty, Liz, Gordon-Smith, Katherine, Grozeva, Detelina ORCID:, Fraser, Christine, Richards, Alexander L., Moran, Jennifer L., Purcell, Shaun, Sklar, Pamela, Kirov, George ORCID:, Owen, Michael J. ORCID:, O'Donovan, Michael C. ORCID:, Craddock, Nick ORCID:, Jones, Lisa ORCID: and Jones, Ian R. ORCID: 2017. Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174 (8) , pp. 767-771. 10.1002/ajmg.b.32572

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Studies have suggested that Research Diagnostic Criteria for Schizoaffective disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP we have performed a replication study using independent RDC-SABP cases (n=144) and controls (n=6,559), focusing on the 10 loci that P-value <10-5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample using ‘researcher-specific SNPs’ represented on the custom array, the ImmunoChip. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n=423, Controls, n=9,494) we observed genome wide significance association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31. This locus did not reach genome wide significance in bipolar disorder or schizophrenia large psychiatric genomic consortium datasets, suggesting that it may be a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley
ISSN: 1552-4841
Date of First Compliant Deposit: 12 September 2017
Date of Acceptance: 30 June 2017
Last Modified: 15 Apr 2024 02:07

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