Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Psychiatric genomics: an update and an agenda

Sullivan, Patrick F., Agrawal, Arpana, Bulik, Cynthia M., Andreassen, Ole A., Børglum, Anders D., Breen, Gerome, Cichon, Sven, Edenberg, Howard J., Faraone, Stephen V., Gelernter, Joel, Mathews, Carol A., Nievergelt, Caroline M., Smoller, Jordan W. and O'Donovan, Michael Conlon ORCID: 2017. Psychiatric genomics: an update and an agenda. American Journal of Psychiatry 175 (1) , pp. 15-27. 10.1176/appi.ajp.2017.17030283

[thumbnail of Psychiatric Genomics.pdf]
PDF - Accepted Post-Print Version
Download (563kB) | Preview


The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver “actionable” findings—genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets. The central idea of the PGC is to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering a phase of accelerated genetic discovery for multiple psychiatric disorders. These findings are likely to elucidate the genetic portions of these truly complex traits, and this knowledge can then be mined for its relevance for improved therapeutics and its impact on psychiatric practice within a precision medicine framework.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: American Psychiatric Association
ISSN: 0002-953X
Date of First Compliant Deposit: 28 February 2018
Date of Acceptance: 15 May 2017
Last Modified: 18 Nov 2023 18:21

Citation Data

Cited 364 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics