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Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics

Wenzel, Margot ORCID:, Meier-Menches, Samuel, Williams, Thomas, Rämisch, Eberhard, Barone, Giampaolo and Casini, Angela ORCID: 2017. Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics. Chemical Communications 54 (6) , pp. 611-614. 10.1039/C7CC08406D

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The binding of Au(III) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Date of First Compliant Deposit: 19 December 2017
Date of Acceptance: 19 December 2017
Last Modified: 06 Nov 2022 04:55

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