Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population

Vaidyanathan, Venkatesh, Naidu, Vijay, Karunasinghe, Nishi, Kao, Chi Hsiu-Juei, Pallati, Radha, Jabed, Anower, Marlow, Gareth ORCID: https://orcid.org/0000-0002-7608-9086, Kallingappa, Prasanna and Ferguson, Lynnette R. 2017. Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population. Molecular BioSystems 13 (10) , pp. 1967-1980. 10.1039/C7MB00203C

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Abstract

Prostate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms are increasingly becoming strong biomarker candidates to identify the susceptibility of individuals to prostate cancer. We carried out risk association of different stages of prostate cancer to a number of single nucleotide polymorphisms to identify the susceptible alleles in a New Zealand population and checked the interaction with environmental factors as well. We identified a number of single nucleotide polymorphisms to have associations specifically to the risk of prostate cancer and aggressiveness of the disease, and also certain single nucleotide polymorphisms to be vulnerable to the reported behavioral factors. We have addressed “special” environmental conditions prevalent in New Zealand, which can be used as a model for a bigger worldwide study.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal Society of Chemistry
ISSN:	1742-206X
Date of First Compliant Deposit:	15 January 2018
Date of Acceptance:	21 July 2017
Last Modified:	04 Dec 2024 00:15
URI:	https://orca.cardiff.ac.uk/id/eprint/108167

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