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Association of combined patterns of tobacco and cannabis use in adolescence with psychotic experiences

Jones, Hannah J., Gage, Suzanne H., Heron, Jon, Hickman, Matthew, Lewis, Glyn, Munafò, Marcus R. and Zammit, Stanley ORCID: 2018. Association of combined patterns of tobacco and cannabis use in adolescence with psychotic experiences. JAMA Psychiatry 75 (3) , pp. 240-246. 10.1001/jamapsychiatry.2017.4271

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Importance There is concern about potentially causal effects of tobacco use on psychosis, but epidemiological studies have been less robust in attempts to minimize effects of confounding than studies of cannabis use have been. Objectives To examine the association of patterns of cigarette and cannabis use with preceding and subsequent psychotic experiences, and to compare effects of confounding across these patterns. Design, Setting, and Participants This cohort study used data from the Avon Longitudinal Study of Parents and Children, which initially consisted of 14 062 children. Data were collected periodically from September 6, 1990, with collection ongoing, and analyzed from August 8, 2016, through June 14, 2017. Cigarette and cannabis use data were summarized using longitudinal latent class analysis to identify longitudinal classes of substance use. Associations between classes and psychotic experiences at age 18 years were assessed. Exposures Depending on the analysis model, exposures were longitudinal classes of substance use or psychotic experiences at age 12 years. Main Outcomes and Measures Logistic regression was used to examine the associations between substance use longitudinal classes and subsequent onset of psychotic experiences.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This is an open access article distributed under the terms of the CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium. You are not required to obtain permission to reuse this article content, provided that you credit the author and journal.
Publisher: American Medical Association (AMA)
ISSN: 2168-622X
Date of First Compliant Deposit: 24 January 2018
Date of Acceptance: 24 November 2017
Last Modified: 06 May 2023 10:16

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