Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

γδ T cell responses: How many ligands will it take till we know?

Vermijlen, David, Gatti, Deborah, Kouzeli, Ariadni, Rus, Teja and Eberl, Matthias ORCID: 2018. γδ T cell responses: How many ligands will it take till we know? Seminars in Cell and Developmental Biology 84 , pp. 75-86. 10.1016/j.semcdb.2017.10.009

[thumbnail of 1-s2.0-S1084952116304335-main.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview
License URL:
License Start date: 5 February 2018


γδ T cells constitute a sizeable and non-redundant fraction of the total T cell pool in all jawed vertebrates, but in contrast to conventional αβ T cells they are not restricted by classical MHC molecules. Progress in our understanding of the role of γδ T cells in the immune system has been hampered, and is being hampered, by the considerable lack of knowledge regarding the antigens γδ T cells respond to. The past few years have seen a wealth of data regarding the TCR repertoires of distinct γδ T cell populations and a growing list of confirmed and proposed molecules that are recognised by γδ T cells in different species. Yet, the physiological contexts underlying the often restricted TCR usage and the chemical diversity of γδ T cell ligands remain largely unclear, and only few structural studies have confirmed direct ligand recognition by the TCR. We here review the latest progress in the identification and validation of putative γδ T cell ligands and discuss the implications of such findings for γδ T cell responses in health and disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1084-9521
Funders: Medical Research Council
Date of First Compliant Deposit: 8 February 2018
Date of Acceptance: 9 October 2017
Last Modified: 06 May 2023 00:49

Citation Data

Cited 54 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics