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Pluripotent stem cell-derived neurons for transplantation in Huntington's disease

Li, Meng ORCID: and Rosser, Anne Elizabeth ORCID: 2017. Pluripotent stem cell-derived neurons for transplantation in Huntington's disease. Howard, Christina J., ed. Functional Neural Transplantation, Progress in Brain Research, Elsevier, pp. 263-281. (10.1016/bs.pbr.2017.02.009)

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Pluripotent stem cells present a potentially unlimited source of cells for regenerative medicine, providing that they can be efficiently and accurately differentiated to the target cell type. The principle target cell for Huntington's disease is the striatal medium spiny neuron. In this chapter, we review strategies for directing medium spiny neuron differentiation, based on known developmental principles, and we discuss the remaining hurdles on the road to engineering such cells for therapeutic application in Huntington's disease.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Advanced Research Computing @ Cardiff (ARCCA)
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Elsevier
ISBN: 9780128118139
Last Modified: 23 Oct 2022 13:18

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