Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented guinea pig

Gliddon, Catherine 2003. Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented guinea pig. Brain Research 964 (2) , pp. 306-310. 10.1016/S0006-8993(02)04086-6

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Abstract

Twelve male pigmented guinea pigs underwent either a unilateral vestibular deafferentation (UVD) (n=6) or sham operation (n=6). Compared to the pre-operated salivary cortisol concentrations, the UVD operation resulted in a significant increase in night cortisol concentrations (P<0.05) and a significant interaction between the night cortisol concentration and time (P<0.05). There was no significant difference between the pre- and post-UVD morning salivary cortisol concentrations; nor between the pre- and post-sham morning or night salivary cortisol concentrations. This study suggests that the ocular–motor and postural syndrome is causing the activation of the hypothalamic–pituitary–adrenal (HPA) axis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0006-8993
Date of Acceptance:	20 November 2002
Last Modified:	09 Jul 2018 14:06
URI:	https://orca.cardiff.ac.uk/id/eprint/111969

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