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Optimization of Zirconium-89 production in IBA cyclone 18/9 cyclotron with COSTIS solid target system

Dabkowski, Adam, Paisey, S. J., Spezi, Emiliano ORCID:, Chester, John ORCID: and Marshall, C. 2017. Optimization of Zirconium-89 production in IBA cyclone 18/9 cyclotron with COSTIS solid target system. Presented at: WTTC16: Proceedings of the 16th International Workshop on Targetry and Target Chemistry, Santa Fe, NM, USA, 29 August–1 September 2016. Published in: Engle, Jonathan W., Barnhart, Todd E., Nortier, Francois M., O’Neil, James P., Birnbaum, Eva R. and Gangon, Katherine M. eds. AIP Conference Proceedings. , vol.1845 Melville, NY: AIP, 020005. 10.1063/1.4983536

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Zirconium-89 is a promising radionuclide in the development of new immuno-PET agents for in vivo imaging of cancerous tumours and radioimmunotherapy (RIT) planning. Besides the convenient half-life of 78.4 h, 89Zr has a beta plus emission rate of 23% and a low maximum energy of 0.9 MeV, delivering good spatial resolution as a result of short positron range in tissue (around 1 mm). Cyclotron production for the radiometal of 89Zr was investigated to find optimal conditions according to results of FLUKA code Monte Carlo modelling of irradiation processes, nuclear reactions and target design. This was followed by reasonably detailed experimental validation (making cyclotron productions for expected high product yield and low impurities levels followed by activity measurements, spectra acquisitions and chemical separation procedures), in which the strategies developed by computer models were carried out in the IBA Cyclone 18/9 cyclotron, permitting a comparison of the predicted and actual yields of 89Zr and isotopic by-products (impurities). Once the in silica model was validated experimentally, then optimal method of the radiometal production in the cyclotron was developed.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: AIP
ISBN: 978-0-7354-1517-1
Last Modified: 06 Jan 2023 02:35

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