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Iron-catalyzed methylation using the borrowing hydrogen approach

Polidano, Kurt, Allen, Benjamin D. W., Williams, Jonathan M. J. and Morrill, Louis C. ORCID: 2018. Iron-catalyzed methylation using the borrowing hydrogen approach. ACS Catalysis 8 , pp. 6440-6445. 10.1021/acscatal.8b02158

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A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 2155-5435
Funders: Engineering and Physical Sciences Research Council
Date of First Compliant Deposit: 18 June 2018
Date of Acceptance: 11 June 2018
Last Modified: 22 Jan 2024 07:26

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