Iron-catalyzed methylation using the borrowing hydrogen approach

Polidano, Kurt, Allen, Benjamin D. W., Williams, Jonathan M. J. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2018. Iron-catalyzed methylation using the borrowing hydrogen approach. ACS Catalysis 8 , pp. 6440-6445. 10.1021/acscatal.8b02158

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Abstract

A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	2155-5435
Funders:	Engineering and Physical Sciences Research Council
Date of First Compliant Deposit:	18 June 2018
Date of Acceptance:	11 June 2018
Last Modified:	22 Jan 2024 07:26
URI:	https://orca.cardiff.ac.uk/id/eprint/112527

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