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Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye

Wang, Ling ORCID:, Hofer, Bernd, Chen, Paul Yen-Po, Guggenheim, Jeremy Andrew ORCID:, Drexler, Wolfgang and Považay, Boris 2010. Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye. Journal of Biomedical Optics 15 (4) , 046004. 10.1117/1.3463480

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We report a high-speed, dispersion-encoded, full-range (DEFR) swept-source optical coherence tomography system for in vivo ocular imaging and biometry of small animals. The fast DEFR algorithm removes the depth ambiguity, gives access to objects located at the zero delay position, and doubles the sampling depth to 2×5.0 mm (at −101 to −71 dB sensitivity) in a single scan using 2048 samples/depth scan 0.43 nm line width of a light source operating at 1056 nm with 70 nm tuning range. The acquisition speed (frames of 512 depth scans in 18.3 ms) permits precise on-line monitoring during positioning and provides cross-sectional views of the mouse eye. Preliminary studies demonstrate high-throughput, reproducible assessment of multiple biometric features (e.g., day-to-day reproducibility of axial length measurement ±5.3 μm) that is insensitive to eye motion sufficient for long-term monitoring.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 28/08/2014)
Publisher: Society of Photo-Optical Instrumentation Engineers
ISSN: 1083-3668
Date of First Compliant Deposit: 30 March 2016
Last Modified: 03 Oct 2023 18:19

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