Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures

Gervasi, Nicolas, Monnier, Zohreh, Vincent, Pierre, Paupardin-Tritsch, Danièle, Hughes, Stuart Wynn, Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 and Leresche, Nathalie 2003. Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. Journal of Neuroscience 23 (36) , pp. 11469-11478.

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Abstract

The systemic injection of -hydroxybutyric acid (GHB) elicits spike and wave discharges (SWDs), the EEG hallmark of absence seizures, and represents a well established, widely used pharmacological model of this nonconvulsive epilepsy. Despite this experimental use of GHB, as well as its therapeutic use in narcolepsy and its increasing abuse, however, the precise cellular mechanisms underlying the different pharmacological actions of this drug are still unclear. Because sensory thalamic nuclei play a key role in the generation of SWDs and sleep rhythms, and because direct injection of GHB in the ventrobasal (VB) thalamus elicits SWDs, we investigated GHB effects on corticothalamic EPSCs and GABAergic IPSCs in VB thalamocortical (TC) neurons. GHB (250

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	GABAB receptors; inhibition; excitation; sleep; intrathalamic oscillations; abuse
Additional Information:	“Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.”http://creativecommons.org/licenses/ See: http://www.jneurosci.org/site/misc/ifa_policies.xhtml
ISSN:	0270-6474
Last Modified:	23 May 2023 22:57
URI:	https://orca.cardiff.ac.uk/id/eprint/1133

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