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Selective Dysgranular Retrosplenial Cortex Lesions in Rats Disrupt Allocentric Performance of the Radial-Arm Maze Task

Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773 and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2005. Selective Dysgranular Retrosplenial Cortex Lesions in Rats Disrupt Allocentric Performance of the Radial-Arm Maze Task. Behavioral Neuroscience 119 (6) , pp. 1682-1686. 10.1037/0735-7044.119.6.1682

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Abstract

The present study provides the 1st report on the effects of selective lesions of the dysgranular portion of the retrosplenial cortex in rats. Excitotoxic lesions of the dysgranular area were sufficient to impair behavior in the radial-arm maze by biasing the strategy used to solve the task. In particular, rats with dysgranular retrosplenial lesions were less reliant on distal visual cues to control performance of a working memory task in the radial-arm maze. Instead, they were more reliant on using a motor turning strategy to solve the task. This change in strategy is consistent with anatomical data showing that the dysgranular region is the primary recipient of visual inputs to the rat retrosplenial cortex.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 07 Nov 2023 11:15
URI: https://orca.cardiff.ac.uk/id/eprint/11371

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