Changes in Fos expression in the rat brain after unilateral lesions of the anterior thalamic nuclei

Jenkins, Trisha A., Dias, Rebecca, Amin, Eman and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2002. Changes in Fos expression in the rat brain after unilateral lesions of the anterior thalamic nuclei. European Journal of Neuroscience 16 (8) , pp. 1425-1432. 10.1046/j.1460-9568.2002.02211.x

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Abstract

Activity of the immediate early gene c-fos was compared across hemispheres in rats with unilateral anterior thalamic lesions. Fos protein was quantified after rats performed a spatial working memory test in the radial-arm maze, a task that is sensitive to bilateral lesions of the anterior thalamic nuclei. Unilateral anterior thalamic lesions produced evidence of a widespread hippocampal hypoactivity, as there were significant reductions in Fos counts in a range of regions within the ipsilateral hippocampal formation (rostral CA1, rostral dentate gyrus, ‘dorsal’ hippocampus, presubiculum and postsubiculum). A decrease in Fos levels was also found in the rostral and caudal retrosplenial cortex but not in the parahippocampal cortices or anterior cingulate cortices. The Fos changes seem most closely linked to sites that are also required for successful task performance, supporting the notion that the anterior thalamus, retrosplenial cortex and hippocampus form key components of an interdependent neuronal network involved in spatial mnemonic processing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	hippocampus; immediate early genes; limbic cortices; retrosplenial cortex; spatial memory; thalamus
Publisher:	Wiley-Blackwell
ISSN:	0953-816X
Last Modified:	18 Oct 2022 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/11389

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