Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome

Tunster, Simon J., Van de Pette, Mathew, Creeth, Hugo D. J., Lefebvre, Louis and John, Rosalind M. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11 , dmm035832. 10.1242/dmm.035832

[thumbnail of Fetal Growth dmm035832.full.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (6MB) | Preview


Beckwith–Wiedemann syndrome (BWS) is a complex imprinting disorder involving fetal overgrowth and placentomegaly, and is associated with a variety of genetic and epigenetic mutations affecting the expression of imprinted genes on human chromosome 11p15.5. Most BWS cases are linked to loss of methylation at the imprint control region 2 (ICR2) within this domain, which in mice regulates the silencing of several maternally expressed imprinted genes. Modelling this disorder in mice is confounded by the unique embryonic requirement for Ascl2, which is imprinted in mice but not in humans. To overcome this issue, we generated a novel model combining a truncation of distal chromosome 7 allele (DelTel7) with transgenic rescue of Ascl2 expression. This novel model recapitulated placentomegaly associated with BWS, but did not lead to fetal overgrowth.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Company of Biologists
ISSN: 1754-8403
Date of First Compliant Deposit: 20 August 2018
Date of Acceptance: 17 August 2018
Last Modified: 24 Mar 2020 17:00

Citation Data

Cited 5 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics