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The origin of cortical surround receptive fields studied in the barrel cortex

Fox, Kevin Dyson ORCID:, Wright, Nicholas, Wallace, Helen and Glasewski, Stanislaw 2003. The origin of cortical surround receptive fields studied in the barrel cortex. Journal of Neuroscience , pp. 8380-8391.

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The neocortex is thought to be organized into functional columns of neurons, each of which processes an element of a larger representation. In the barrel cortex, the thalamic input to the column preferentially terminates in a barrel. To study the extent and nature of functional connections between columns, we measured the degree to which whisker responses are relayed between columns in the barrel cortex. Inactivating a single barrel by iontophoresis of the GABAA agonist muscimol abolished the representation of that barrel's whisker in neighboring barrels. Reactivating a single barrel by iontophoresis of the GABAA antagonist bicuculline while the rest of the cortex was blocked by muscimol led to single whisker receptive fields. Under the same conditions, septal cells tended to exhibit multiwhisker receptive fields. These studies demonstrate that the surround receptive fields of barrel cells are generated by intracortical transmission and that many septal cells derive a component of their surround receptive field from the thalamus.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: barrels; whiskers; GABA; rat; sensory processing; muscimol
Additional Information: “Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.” See:
ISSN: 0270-6474
Last Modified: 05 May 2023 22:26

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