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Type 3 secretion effectors

Clements, Abigail, Berger, Cedric N. ORCID:, Lomma, Mariella and Frankel, Gad 2013. Type 3 secretion effectors. Escherichia Coli: Pathotypes and Principles of Pathogenesis 2nd ed., Academic Pess, pp. 451-497. (10.1016/B978-0-12-397048-0.00015-2)

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Enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), and Shigella use a type 3 secretion system (T3SS) to inject dozens of effector proteins into the host cell. The effectors manipulate host cell processes including the host cytoskeleton, immune response, cell survival, and gut integrity. EPEC and EHEC share a large number of common effectors and some homologous effectors can be found in Shigella, however there is also considerable variability within and between pathotypes. For many effectors detailed molecular mechanisms of action have been described by identifying host interacting partners, homologous proteins, or enzymatic activities. However, understanding effector biology within the context of infection with multiple effectors, various cell populations, and host genetic differences remains a challenge.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Academic Pess
ISBN: 978-0-12-397048-0
Last Modified: 24 Oct 2022 07:21

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