Evolution of hyperacute stroke over 6 hours using serial MR perfusion and diffusion maps

Harris, Ashley D., Kosior, Robert K., Chen, Henry S., Andersen, Linda B. and Frayne, Richard 2009. Evolution of hyperacute stroke over 6 hours using serial MR perfusion and diffusion maps. Journal of Magnetic Resonance Imaging 29 (6) , pp. 1262-1270. 10.1002/jmri.21763

Full text not available from this repository.

Abstract

Purpose: To develop an appropriate method to evaluate the time-course of diffusion and perfusion changes in a clinically relevant animal model of ischemic stroke and to examine lesion progression on MR images. An exploration of acute stroke infarct expansion was performed in this study by using a new methodology for developing time-to-infarct maps based on the time at which each voxel becomes infarcted. This enabled definition of homogeneous regions from the heterogeneous stroke infarct. Materials and Methods: Time-to-infarct maps were developed based on apparent diffusion coefficient (ADC) changes. These maps were validated and then applied to blood flow and time-to-peak maps to examine perfusion changes. Results: ADC stroke infarct showed different evolution patterns depending on the time at which that region of tissue infarcted. Applying the time-to-infarct maps to the perfusion maps showed localized perfusion evolution characteristics. In some regions, perfusion was immediately affected and showed little change over the experiment; however, in some regions perfusion changes were more dynamic. Conclusion: Results were consistent with the diffusionperfusion mismatch hypothesis. In addition, characteristics of collateral recruitment were identified, which has interesting stroke pathophysiology and treatment implications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	acute ischemic stroke ; perfusion-weighted imaging ; diffusion-weighted imaging ; diffusion-perfusion mismatch.
Publisher:	John Wiley & Sons
ISSN:	1053-1807
Last Modified:	10 Oct 2017 13:19
URI:	https://orca.cardiff.ac.uk/id/eprint/11539

Citation Data

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item