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Candida auris dry surface biofilm (DSB) for disinfectant efficacy testing

Ledwoch, Katarzyna and Maillard, Jean-Yves ORCID: 2019. Candida auris dry surface biofilm (DSB) for disinfectant efficacy testing. Materials 12 (1) , p. 18. 10.3390/ma12010018

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Candida auris is an emerging pathogen that needs to be controlled effectively due to its association with a high mortality rate. The presence of biofilms on dry surfaces has been shown to be widespread in healthcare settings. We produced a C. auris dry surface biofilm (DSB) on stainless steel surfaces following sequential hydration and desiccation cycles for 12 days. The ASTM2967-15 was used to measure the reduction in viability of 12 commercially wipe-based disinfectants and sodium hypochlorite (1000 ppm) against C. auris DSB. We also evaluated C. auris transferability and biofilm regrowth post-treatment. A peracetic acid (3500 ppm) product and two chlorine-based products (1000 ppm available chlorine) were successful in reducing C. auris viability and delaying DSB regrowth. However, 50% of the products tested failed to decrease C. auris viability, 58% failed to prevent its transferability, and 75% did not delay biofilm regrowth. Using three different parameters to measure product efficacy provided a practical evaluation of product effectiveness against C. auris DSB. Although log10 reduction in viability is traditionally measured, transferability is an important factor to consider from an infection control and prevention point of view as it allows for determination of whether the surface is safe to touch by patients and hospital staff post-treatment

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: MDPI
ISSN: 1996-1944
Date of First Compliant Deposit: 2 January 2019
Date of Acceptance: 14 December 2018
Last Modified: 05 May 2023 12:32

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