Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tracking hole transport in DNA hairpins using a phenylethynylguanine nucleobase

Brown, Kristen E., Singh, Arunoday P. N., Wu, Yi-Lin ORCID:, Mishra, Ashutosh Kumar, Zhou, Jiawang, Lewis, Frederick D., Young, Ryan M. and Wasielewski, Michael R. 2017. Tracking hole transport in DNA hairpins using a phenylethynylguanine nucleobase. Journal of the American Chemical Society 139 (34) , pp. 12084-12092. 10.1021/jacs.7b06998

[thumbnail of jacs.7b06998 postprint.pdf]
PDF - Accepted Post-Print Version
Download (1MB) | Preview


The hole transport dynamics of DNA hairpins possessing a stilbene electron acceptor and donor along with a modified guanine (G) nucleobase, specifically 8-(4′-phenylethynyl)deoxyguanosine, or EG, have been investigated. The nearly indistinguishable oxidation potentials of EG and G and unique spectroscopic characteristics of EG+• make it well-suited for directly observing transient hole occupation during charge transport between a stilbene electron donor and acceptor. In contrast to the cation radical G+•, EG+• possesses a strong absorption near 460 nm and has a distinct Raman-active ethynyl stretch. Both spectroscopic characteristics are easily distinguished from those of the stilbene donor/acceptor radical ion chromophores. Employing EG, we observe its role as a shallow hole trap, or as an intermediate hole transport site when a deeper trap state is present. Using a combination of ultrafast absorption and stimulated Raman spectroscopies, the hole-transport dynamics are observed to be similar in systems having EG vs G bases, with small perturbations to the charge transport rates and yields. These results show EG can be deployed at specified locations throughout the sequence to report on hole occupancy, thereby enabling detailed monitoring of the hole transport dynamics with base-site specificity

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 0002-7863
Date of First Compliant Deposit: 11 January 2019
Date of Acceptance: 2 August 2017
Last Modified: 06 Nov 2023 23:52

Citation Data

Cited 10 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics