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Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

Jeltsch, Albert, Ehrenhofer-Murray, Ann, Jurkowski, Tomasz P ORCID:, Lyko, Frank, Reuter, Gunter, Ankri, Serge, Nellen, Wolfgang, Schaefer, Matthias and Helm, Mark 2016. Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. RNA Biology 14 (9) , 1108—1123. 10.1080/15476286.2016.1191737

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A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Landes Bioscience
ISSN: 1547-6286
Date of First Compliant Deposit: 5 February 2019
Date of Acceptance: 13 May 2016
Last Modified: 25 Oct 2022 13:08

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