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Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

Ariotti, S., Beltman, J.B., Chodaczek, G., Hoekstra, M.E., Van Beek, A.E., Gomez-Eerland, R., Ritsma, L., Van Rheenen, J., Maree, A.F.M. ORCID:, Zal, T., De Boer, R.J., Haanen, J.B.A.G. and Schumacher, T.N. 2012. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proceedings of the National Academy of Sciences of the United States of America 109 (48) , pp. 19739-19744. 10.1073/pnas.1208927109

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Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they encounter newly infected target cells. Here we demonstrate that antigen-specific CD8+ T cells that remain in skin following herpes simplex virus infection show a steady-state crawling behavior in between keratinocytes. Spatially explicit simulations of the migration of these tissue-resident memory T cells indicate that the migratory dendritic behavior of these cells allows the detection of antigen-expressing target cells in physiologically relevant time frames of minutes to hours. Furthermore, we provide direct evidence for the identification of rare antigen-expressing epithelial cells by skin-patrolling memory T cells in vivo. These data demonstrate the existence of skin patrol by memory T cells and reveal the value of this patrol in the rapid detection of renewed infections at a previously infected site.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: National Academy of Sciences
ISSN: 0027-8424
Date of Acceptance: 9 October 2012
Last Modified: 25 Oct 2022 13:18

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