Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Spatial modelling of brief and long interactions between T cells and dendritic cells

Beltman, J.B., Maree, A.F.M. and De Boer, R.J. 2007. Spatial modelling of brief and long interactions between T cells and dendritic cells. Immunology and Cell Biology 85 (4) , pp. 306-314. 10.1038/sj.icb.7100054

Full text not available from this repository.

Abstract

In the early phases of an immune response, T cells of appropriate antigen specificity become activated by antigen‐presenting cells in secondary lymphoid organs. Two‐photon microscopy imaging experiments have shown that this stimulation occurs in distinct stages during which T cells exhibit different motilities and interactions with dendritic cells (DCs). In this paper, we utilize the Cellular Potts Model, a model formalism that takes cell shapes and cellular interactions explicitly into account, to simulate the dynamics of, and interactions between, T cells and DCs in the lymph node paracortex. Our three‐dimensional simulations suggest that the initial decrease in T‐cell motility after antigen appearance is due to ‘stop signals’ transmitted by activated DCs to T cells. The long‐lived interactions that occur at a later stage can only be explained by the presence of both stop signals and a high adhesion between specific T cells and antigen‐bearing DCs. Furthermore, our results indicate that long‐lasting contacts with T cells are promoted when DCs retract dendrites that detect a specific contact at lower velocities than other dendrites. Finally, by performing long simulations (after prior fitting to short time scale data) we are able to provide an estimate of the average contact duration between T cells and DCs.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Nature Publishing Group
ISSN: 0818-9641
Last Modified: 18 Feb 2019 08:45
URI: https://orca.cardiff.ac.uk/id/eprint/119485

Citation Data

Cited 48 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item