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The RNA silencing pathway: The bits and pieces that matter

Groenenboom, M.A.C., Maree, A.F.M. and Hogeweg, P. 2005. The RNA silencing pathway: The bits and pieces that matter. PLoS Computational Biology 1 (2) , 0155-0165. 10.1371/journal.pcbi.0010021

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Abstract

Cellular pathways are generally proposed on the basis of available experimental knowledge. The proposed pathways, however, may be inadequate to describe the phenomena they are supposed to explain. For instance, by means of concise mathematical models we are able to reveal shortcomings in the current description of the pathway of RNA silencing. The silencing pathway operates by cleaving siRNAs from dsRNA. siRNAs can associate with RISC, leading to the degradation of the target mRNA. We propose and analyze a few small extensions to the pathway: a siRNA degrading RNase, primed amplification of aberrant RNA pieces, and cooperation between aberrant RNA to trigger amplification. These extensions allow for a consistent explanation for various types of silencing phenomena, such as virus induced silencing, transgene and transposon induced silencing, and avoidance of self-reactivity, as well as for differences found between species groups.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Public Library of Science
ISSN: 1553-734X
Date of Acceptance: 29 June 2005
Last Modified: 18 Feb 2019 14:30
URI: https://orca.cardiff.ac.uk/id/eprint/119494

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