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Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Balogi, Zsolt, Multhoff, Gabrielle, Jensen, Thomas Kirkegaard, Lloyd-Evans, Emyr ORCID:, Yamashima, Tetsumori, Jäättelä, Marja, Harwood, John L. ORCID: and Vígh, László 2019. Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. Progress in Lipid Research 74 , pp. 18-30. 10.1016/j.plipres.2019.01.004

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Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70 in the context of its therapeutic potential, particularly in cancer and neurodegenerative diseases

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0163-7827
Date of First Compliant Deposit: 14 February 2019
Date of Acceptance: 28 January 2019
Last Modified: 26 Oct 2022 04:39

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