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Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models

Pinho, Jacinta, Amaral, Joana, Castro, Rui, Rodrigues, Cecilia, Casini, Angela ORCID:, Soveral, Graca and Gaspar, Manuela 2019. Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models. Nanomedicine 14 (7) 10.2217/nnm-2018-0388

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Aim: Preclinical evaluation of a cytotoxic copper(II) complex formulated in long circulating nanoliposomes for melanoma treatment. Materials & methods: Liposomal nanoformulations of the copper complex were characterized in terms of thermodynamic behavior (differential scanning calorimeter), pH-sensitivity (spectrophotometry) and antiproliferative effects against murine melanoma B16F10 cells in vitro. Preclinical studies were performed in a C57BL/6 syngeneic melanoma model. Results: Nanoformulations were thermodynamically stable, and CHEMS-containing nanoliposomes were pH-sensitive and preserved the antiproliferative properties of the copper compound. These nanoformulations significantly impaired tumor progression in vivo, devoid of toxic side effects, compared with control mice or mice treated with the free metallodrug. Conclusion: Copper complex-containing nanoliposomes demonstrate high anticancer efficacy and safety, constituting a step forward to the development of more effective therapeutic strategies against melanoma.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Future Medicine
ISSN: 1743-5889
Date of First Compliant Deposit: 13 March 2019
Date of Acceptance: 14 December 2018
Last Modified: 28 Oct 2022 02:01

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