Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Waiting impulsivity: the influence of acute methylphenidate and feedback

Voon, V., Chang-Webb, Y.C., Morris, L.S., Cooper, E., Sethi, A., Baek, K., Grant, J., Robbins, T.W. and Harrison, N.A. ORCID: 2016. Waiting impulsivity: the influence of acute methylphenidate and feedback. International Journal of Neuropsychopharmacology 19 (1) , pp. 1-10. 10.1093/ijnp/pyv074

[thumbnail of pyv074.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview


Background: The ability to wait and to weigh evidence is critical to behavioral regulation. These behaviors are known as waiting and reflection impulsivity. In Study 1, we examined the effects of methylphenidate, a dopamine and norepinephrine reuptake inhibitor, on waiting and reflection impulsivity in healthy young individuals. In study 2, we assessed the role of learning from feedback in disorders of addiction. Methods: We used the recently developed 4-Choice Serial Reaction Time task and the Beads task. Twenty-eight healthy volunteers were tested twice in a randomized, double-blind, placebo-controlled cross-over trial with 20mg methylphenidate. In the second study, we analyzed premature responses as a function of prior feedback in disorders of addiction. Results: Study 1: Methylphenidate was associated with greater waiting impulsivity to a cue predicting reward along with faster responding to target onset without a generalized effect on reaction time or attention. Methylphenidate influenced reflection impulsivity based on baseline impulsivity. Study 2: More premature responses occurred after premature responses in stimulant-dependent subjects. Conclusions: We show that methylphenidate has dissociable effects on waiting and reflection impulsivity. Chronic stimulant exposure impairs learning from prior premature responses, suggesting a failure to learn that premature responding is suboptimal. These findings provide a greater mechanistic understanding of waiting impulsivity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Cambridge University Press (CUP)
ISSN: 1461-1457
Date of First Compliant Deposit: 17 September 2019
Date of Acceptance: 24 June 2015
Last Modified: 06 May 2023 03:55

Citation Data

Cited 15 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics