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Metal-free oxidative fluorination of phenols with [18F]fluoride

Gao, Zhanghua, Lim, Yee Hwee, Tredwell, Matthew ORCID:, Li, Lei, Verhoog, Stefan, Hopkinson, Matthew, Kaluza, Wojciech, Collier, Thomas Lee, Passchier, Jan, Huiban, Mickael and Gouverneur, Veronique 2012. Metal-free oxidative fluorination of phenols with [18F]fluoride. Angewandte Chemie International Edition 51 (27) , pp. 6733-6737. 10.1002/anie.201201502

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The radiochemical synthesis of [18F]4‐fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra‐n‐butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O‐unprotected 4‐tert‐butyl phenols are used as precursors in this one‐pot protocol. The reaction is completed in less than 30 minutes at room temperature and can be performed using standard or microfluidic technology.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 1433-7851
Last Modified: 04 Nov 2022 12:11

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