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Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols

Dambatta, Mubarak, Polidano, Kurt, Northey, Alexander D., Williams, Jonathan M. J. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2019. Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols. ChemSusChem 12 (11) , pp. 2345-2349. 10.1002/cssc.201900799

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Abstract

A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employs a (cyclopentadienone)iron carbonyl complex (2 mol %) and exhibits a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles undergo selective monoC(3)-alkylation in good to excellent isolated yields (28 examples, 50- 92% yield, 79% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 1864-5631
Funders: EPSRC
Date of First Compliant Deposit: 14 May 2019
Date of Acceptance: 8 April 2019
Last Modified: 07 Nov 2022 19:35
URI: https://orca.cardiff.ac.uk/id/eprint/122469

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