Dambatta, Mubarak, Polidano, Kurt, Northey, Alexander D., Williams, Jonathan M. J. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2019. Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols. ChemSusChem 12 (11) , pp. 2345-2349. 10.1002/cssc.201900799 |
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Official URL: http://dx.doi.org/10.1002/cssc.201900799
Abstract
A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employs a (cyclopentadienone)iron carbonyl complex (2 mol %) and exhibits a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles undergo selective monoC(3)-alkylation in good to excellent isolated yields (28 examples, 50- 92% yield, 79% average yield).
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | Wiley |
ISSN: | 1864-5631 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 14 May 2019 |
Date of Acceptance: | 8 April 2019 |
Last Modified: | 25 Aug 2024 21:33 |
URI: | https://orca.cardiff.ac.uk/id/eprint/122469 |
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